Media enquiries
2 Marsham Street
London
SW1P 4DF
Press enquiries 020 7XXX XXXX
Out of hours 020 7XXX XXXX
A comment about the contact
Common elements
Heading 2
Paragraph of text, containing some words, such as the word 'words'. I know all the words.
Heading 3
Another paragraph of text, containing some more words, now including 'including'. These words are longer and more exciting, particularly 'exciting', which is genuinely a thrill to see on such a page as this.
- An unordered list item.
- Another unordered list item.
- Yet another unordered list item.
A paragraph of text following the list. I'm not going to talk about the words anymore.
This text is inside a blockquote.
Yet another paragraph of text. This is starting to sound familiar.
-
An ordered list, this time containing paragraphs in the list items.
It's not common that this happens, but it does occur and we need to be aware of it and make sure the layout works consistently.
-
Still an ordered list, also containing a paragraph.
Another heading 3
And another paragraph.
-
This is known as steps.
-
And this too.
And another paragraph.
This is a warning callout box.
And another paragraph.
This is a warning callout box inside a call to action.
Heading 3
And another paragraph.
| Animal | Size | Legs | Rhymes with | Special abilities |
|---|---|---|---|---|
| Sheep | Medium | Four | Jeep, heap, deep, sleep, keep. | Growing wool on itself that can be harvested and used for clothing. |
| Cow | Large | Four | Now, how, bow, wow. | Has four stomachs. |
This is a paragraph, and now for an address.
First line of address
Second line of address
75 This street
United Kingdom
Phone: 07123456789
This is a paragraph, and now for a contact.
An attachment as a block
Example
This is an indented example block.
It may span multiple lines, contain links.
It may even span multiple paragraphs.
This is another paragraph.
This is an information callout.
This is a warning callout.
This is a text with a footnote1.
Rtl block
قال وزير الخارجية، ويليام هيغ:
مع بدء هذا الشهر الفضيل أتمنى للمسلمين في أنحاء العالم - في آسيا وأفريقيا والشرق الأوسط وأوروبا وغيرها من مناطق العالم - شهر رمضان مبارك.
في المملكة المتحدة يُحتفل بشهر رمضان منذ أجيال عديدة، ونفتخر بروابطنا القوية مع العالم الإسلامي، سواء مع شركائنا المعهودين في الشرق الأوسط أو روابطنا التاريخية المتينة في آسيا وأفريقيا أو مواطنينا المسلمين البريطانيين المفعمين بالحيوية والنشاط.
ordered list
- تابع الوزير أليستر بيرت عبر تويتر
- تابعنا باللغة العربية عبر
- تابعنا باللغة العربية عبر تويتر
unordered list
- تابع الوزير أليستر بيرت عبر تويتر
- تابعنا باللغة العربية عبر
- تابعنا باللغة العربية عبر تويتر
| السنة | الدور |
|---|---|
| 2020 - 2022 | وزارة الخارجية والتنمية البريطانية |
| 2016 - 2020 | القنصل العام البريطاني في القنصلية البريطانية العامة في شونغشينغ |
| 2012 - 2015 | الدوحة، نائب رئيس البعثة |
Address
First line of address
Second line of address
75 This street
United Kingdom
Phone: 07123456789
Addresses are generated when using the `$A` markdown pattern.
Attachment link
A reference to my that is in my paragraph.
Attachment
An attachment as a block
Another attachment as a block
Attachment inline
testing my attachment works in the middle of copy.
Blockquote
My quote
about things
Call to action
Call to action
Information callout
If you drilled a tunnel straight through the Earth and jumped in, it would take you exactly 42 minutes and 12 seconds to get to the other side.
Warning callout
The water in the mouth of a blue whale weighs more than its body.
Contact
Media enquiries
2 Marsham Street
London
SW1P 4DF
Press enquiries 020 7XXX XXXX
Out of hours 020 7XXX XXXX
A comment about the contact
Charts
| row 1 | 10 |
| row 2 | 15 |
| row 3 | 2 |
| row 4 | 48 |
Chart with colours
| Number position | Apples | Oranges | Bananas | Pears | Grapes | Strawberries | Plums |
|---|---|---|---|---|---|---|---|
| Numbers inside bar | 16 | 48 | 39 | 50 | 24 | 10 | 62 |
| Numbers outside bar | 2 | 1 | 2 | 1 | 1 | 2 | 1 |
Chart with multiple headings
| Some Data | YES | NO | MAYBE |
|---|---|---|---|
| Testing One | 5 | 6 | 11 |
| Testing Two | 6 | 2 | 8 |
| Testing Three | 3 | 9 | 12 |
Chart stacked
| Colours | Fruits | Vegetables | Beans | Nuts | Total |
|---|---|---|---|---|---|
| Red | 23 | 9 | 2 | 1 | 35 |
| Green | 5 | 33 | 8 | 0 | 46 |
| Yellow | 2 | 10 | 0 | 15 | 27 |
Example
Example
This is an indented example block.
It may span multiple lines, contain links.
It may even span multiple paragraphs.
Image fractions
Number - fractions
Pupils should be taught to:
- recognise, find, name and write fractions
,
,
and
of a length, shape, set of objects or quantity - write simple fractions, for example
of 6 = 3 and recognise the equivalence of
and
Notes and guidance (non-statutory)
Pupils use fractions as ‘fractions of’ discrete and continuous quantities by solving problems using shapes, objects and quantities. They connect unit fractions to equal sharing and grouping, to numbers when they can be calculated, and to measures, finding fractions of lengths, quantities, sets of objects or shapes. They meet
as the first example of a non-unit fraction.
Pupils should count in fractions up to 10, starting from any number and using the
and
equivalence on the number line (for example, 1
, 1
(or 1
), 1
, 2). This reinforces the concept of fractions as numbers and that they can add up to more than 1.
Text fractions
If an image is not available for a particular fraction, then we'll fallback to text based fraction using sup/sub, like this 1⁄100 example.
Highlight answer
The VAT rate is 20%
In the 2017 to 2018 tax year, the savings limit for Junior ISAs is £4,128
In the 2017 to 2018 tax year, the maximum you can save in ISAs is £20,000
Heading levels
This is a h2 title
This is a h3 title
This is a h4 title
This is a h5 title
This is a h6 title
Image
Deforested area. Credit: Blue Ventures-Garth Cripps
Lists
ordered list:
- one
- two
- three
unordered list:
- one
- two
- three
Legislative lists
ordered list:
- one
- two
- three
Nested lists
ordered list:
-
- one
- two
- three
unordered list:
-
- one
- two
- three
Ordered lists types
Lowercase alphabetical list
- one
- two
Uppercase alphabetical list
- one
- two
Lowercase Roman numeral list
- one
- two
Uppercase Roman numberal list
- one
- two
Numerical list starting at 3
- three
- four
Lowercase alphabetical list, starting at 3
- three
- four
Steps
-
Add numbers.
-
Check numbers.
-
Love numbers.
Place
This is a place
Statistic headlines
£6bn Total Departmental Expenditure Limit (DEL) in financial year 2015 to 2016
This includes £5.8 billion Resource DEL and £0.2 billion Capital DEL. In addition, DWP Annually Managed Expenditure (AME) in financial year 2015 to 2016 is £170.5 billion, as forecast by the Office for Budget Responsibility.
UK employment rate 74.1% between October and December 2015
Specialist content
Bisphosphonates
Bisphosphonates are used to treat osteoporosis, Paget’s disease, and as part of some cancer regimens, particularly for metastatic bone cancer and multiple myeloma. Individual bisphosphonates have different indications (see individual Summaries of Product Characteristics1). The following bisphosphonates are available in the UK:
- Alendronic acid
- Ibandronic acid
- Pamidronate disodium
- Risedronate sodium
- Sodium clodronate
- Zoledronic acid
Osteonecrosis of the external auditory canal
Benign idiopathic osteonecrosis of the external auditory canal is a rare condition that can occur in the absence of antiresorptive therapy and is sometimes associated with local trauma.
Advice for healthcare professionals:
- The possibility of osteonecrosis of the external auditory canal should be considered in patients receiving bisphosphonates who present with ear symptoms, including chronic ear infections, or in patients with suspected cholesteatoma
- Possible risk factors include steroid use and chemotherapy, with or without local risk factors such as infection or trauma
- Patients should be advised to report any ear pain, discharge from the ear, or an ear infection during bisphosphonate treatment
- Report any cases of osteonecrosis of the external auditory canal suspected to be associated with bisphosphonates or any other medicines, including denosumab, on a Yellow Card
Evidence for an association with bisphosphonate treatment
Evidence from the clinical literature and from cases reported to medicines regulators, including one report received via the UK Yellow Card scheme, supports a causal association between bisphosphonates and osteonecrosis of the external auditory canal. Product information is being updated to include advice for healthcare professionals and patients.
A total of 29 reports indicative of osteonecrosis of the external auditory canal in association with bisphosphonates have been identified worldwide, including 11 cases reported in the clinical literature.2 3 4 5 6 7 8 Cases have been reported with use of both intravenous or oral bisphosphonates for both cancer-related or osteoporosis indications; there is currently insufficient evidence to determine whether there is any increased risk with higher doses used for cancer-related conditions. Most cases were associated with long-term bisphosphonate therapy for 2 years or longer, and most cases had possible risk factors including: steroid use; chemotherapy; and possible local risk factors such as infection, an ear operation, or cotton-bud use. Bilateral osteonecrosis of the external ear canal was reported in some patients, as was osteonecrosis of the jaw.
The number of cases of osteonecrosis of the external auditory canal reported in association with bisphosphonates is low compared with the number of cases reported of bisphosphonate-related osteonecrosis of the jaw, a well-established side effect of bisphosphonates.9
Evidence for an association with denosumab treatment
The available data do not support a causal relation between osteonecrosis of the external auditory canal and denosumab. However, this possible risk is being kept under close review, given that denosumab is known to be associated with osteonecrosis of the jaw.
Article citation: Drug Safety Update volume 9 issue 5 December 2015: 3.
-
Summaries of Product Characteristics can be found here on the MHRA website or on the website of the European Medicines Agency, depending whether the medicine has a national or European licence, respectively. ↩
-
Bast F, et al. Bilateral bisphosphonate-associated osteonecrosis of the external ear canal: a rare case. HNO. 2012; 60: 1127–29 [in German]. ↩
-
Froelich K, et al. Bisphosphonate-induced osteonecrosis of the external ear canal: a retrospective study. Eur Arch Otorhinolaryngol 2011; 268: 1219–25. ↩
-
Kharazmi M, et al. Bisphosphonate-associated osteonecrosis of the auditory canal. Br J Oral Maxillofac Surg 2013; 51: e285–87. ↩
-
Polizzotto MN, et al. Bisphosphonate-associated osteonecrosis of the auditory canal. Br J Haematol 2006; 132: 114. ↩
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Salzman R, et al. Osteonecrosis of the external auditory canal associated with oral bisphosphonate therapy: case report and literature review. Otol Neurotol 2013; 34: 209–13. ↩
-
Thorsteinsson AL, et al. Bisphosphonate-induced osteonecrosis of the external auditory canal: a case report. J Clin Med Case Reports 2015; 2: 3. ↩
-
Wickham N, et al. Bisphosphonate-associated osteonecrosis of the external auditory canal. J Laryngol Otol 2013; 127 (suppl 2): S51–53. ↩
-
Patient reminder cards about the risk of osteonecrosis of the jaw are being introduced for intravenous bisphosphonates and denosumab. The cards will become available at different times for individual products. They are now available for the following products: Prolia (denosumab); Xgeva (denosumab); Aclasta (zoledronic acid); Zometa (zoledronic acid); zoledronic acid 5 mg generics and zoledronic acid 4 mg generics. The cards can be viewed here. ↩
Tables
| Group | Explanation | Current and continuing guidance | Government support |
|---|---|---|---|
| Clinically extremely vulnerable people (all people in this cohort will have received communication from the NHS) | People defined on medical grounds a clinically extremely vulnerable, meaning they are at the greatest risk of severe illness. This group includes solid organ transplant recipients, people receiving chemotherapy, renal dialysis patients and others. | Follow shielding guidance by staying at home at all times and avoiding all non-essential face-to-face contact. This guidance is in place until end June. | Support available from the National Shielding Programme, which includes food supplies (through food boxes and priority supermarket deliveries), pharmacy deliveries and care. Support is available via the NHS Volunteer Responders app. |
| Clinically vulnerable people | People considered to be at higher risk of severe illness from COVID-19. Clinically vulnerable people include the following: people aged 70 or older, people with liver disease, people with diabetes, pregnant women and others. | Stay at home as much as possible. If you do go out, take particular care to minimise contact with others outside your household. | Range of support available while measures in place, including by local authorities and through voluntary and community groups. Support is available via the NHS Volunteer Responders app. |
| Vulnerable people (non-clinical) | There are a range of people who can be classified as ‘vulnerable’ due to non-clinical factors, such as children at risk of violence or with special education needs, victims of domestic abuse, rough sleepers and others. | People in this group will need to follow general guidance except where they are also clinically vulnerable or clinically extremely vulnerable, where they should follow guidance as set out above. | For those who need it, a range of support and guidance across public services and the benefits system, including by central and local government and the voluntary and community sector. |
Tables with alignments
| Default aligned | Left aligned | Center aligned | Right aligned |
|---|---|---|---|
| First body part | Second cell | Third cell | fourth cell |
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